SKINMED® ROSAGATE® PROFESSIONAL (SOS)

Overview

Advanced Clinical Treatment for Rosacea & Inflammatory Skin Conditions

Rosagate® Professional works by inhibiting key inflammatory enzymes and calming immune overreactions:

RO-Peptide 23: A synthetic peptide derived from cathelicidin, by inhibiting kallikrein 5 & 7, enzymes responsible for triggering excessive immune responses, thereby restricting the development of papules and pustules while also maintaining effective barrier function and reducing inflammasome development to counter vascular symptoms
MSM: inhibits cytokines and vaso endothelial growth factor to reduce excessive vascular development and and to counter the length depth and frequency of flushes
4-T-Butylcyclohexanol: Reduces sensory discomfort which counters burning stinging and redness caused by dysregulated neurogenic pathways

These ingredients collectively help:

Improve skin barrier function
Decrease papules and pustules
Reduce flushing, telangiectasia, and skin reactivity

What It Treats

✅ Erythematotelangiectatic Rosacea (Subtype 1)
✅ Papulopustular Rosacea (Subtype 2)
✅ Sunburn & Mild Scalding
✅ Post-Laser & Post-Plasma Erythema
✅ As a glide medium for microneedling
✅ Supportive care in inflammatory pigmentation protocols

Science-Backed Ingredients

Rosagate® Professional works by inhibiting key inflammatory enzymes and calming immune overreactions:

RO-Peptide 23: A synthetic peptide derived from cathelicidin, it inhibits kallikrein 5 & 7, enzymes responsible for triggering excessive immune responses and inflammation.
MSM: Soothes irritation and supports skin health.
4-T-Butylcyclohexanol: Reduces sensory discomfort and visible redness.

These ingredients collectively help:

Improve skin barrier function
Decrease papules and pustules
Reduce flushing, telangiectasia, and skin reactivity

In-Clinic & At-Home Regimen

In-Clinic & At-Home Regimen

For continuous care, Rosagate® TripleLock® products include the clinic-grade actives but also incorporate synergistic ingredients to add to the results such as magnolol :

Rosagate® 24hr Active Cream – Includes 4 clinical actives MSM, silymarin, 4-T-butylcyclohexanol and Polyglutamic acid
Rosagate® SPF 50 – With Magnolol for added anti-inflammatory action plus MSM, 4-T-butylcyclohexanol and Polyglutamic acid
Rosagate® Mask – Ideal night time rebalancing gel with RO-Peptide 23 to continue to target papule and pustule development and vascular flare ups.
Also used to calm post treatment erythema and doubles as a dermal needling glide medium

🔄 These work synergistically with Rosagate® Professional to maintain results between treatments.

Clinical Results & Protocol Benefits

Shortens and reduces rosacea flare-ups
Reduces nerve-triggered redness and hormonal triggers
Strengthens damaged blood vessels and reduces visibility
Protects collagen matrix from angiogenic damage
Reduces cathelicidin activity → fewer pustules, better skin barrier
Modulates Substance P and VEGF → less new vessel formation
Helps prevent phymas (e.g. nose swelling) and glandular thickening
Reduces the risk of ocular rosacea

Application

Used in-clinic by professionals:

Step 1: Functional solution applied with a brush and left to absorb for 20+ minutes.
Step 2: An invisible mask seals in the actives—no residue left behind.